Anna Domino (born 1955, Anna Virginia Taylor) is an American indie rock artist based in New York and Los Angeles who released several albums for Les Disques du Crepuscule and Factory Records in the 1980s and 1990s. Domino has collaborated with musicians such as Matt Johnson of The The, Stephin Merritt in The Sixths, Blaine L. Reininger and Steven Brown of Tuxedomoon, Virginia Astley, Luc van Acker and Ultramarine. She is also one half of the duo Snakefarm.

Her stage name was borrowed from the Domino Sugar company in NY and is also a play on the term Anno Domini.