Santo & Johnny were an American rock and roll instrumental duo of Italian descent from Brooklyn, New York, composed of brothers Santo Farina (born October 24, 1937) and Johnny Farina (born April 30, 1941).

They are known best for their instrumental melody "Sleep Walk", one of the biggest hits of the golden age of rock 'n' roll, which became a regional success and eventually scored the top of the Billboard pop chart when it was released nationally during 1959.