The B-52s, originally presented as the B-52's (with an apostrophe; used until 2008), are an American new wave band formed in Athens, Georgia, in 1976. The original lineup consisted of Fred Schneider (vocals, percussion), Kate Pierson (vocals, keyboards, synth bass), Cindy Wilson (vocals, percussion), Ricky Wilson (guitar), and Keith Strickland (drums, guitar, keyboards). Ricky Wilson died of AIDS-related illness in 1985, and Strickland switched from drums to lead guitar. The band has also added various members for albums and live performances.

The B-52s have had many hits, including "Rock Lobster", "Planet Claire", "Party Out of Bounds", "Private Idaho", "Whammy Kiss", "Summer of Love", "Wig", "Love Shack", "Roam" and "(Meet) The Flintstones". They have been nominated for three Grammy Awards: twice for Best Pop Performance by a Duo or Group in 1990 and 1991, and for Best Alternative Music Album in 1992. In April 2022, the group announced they were retiring from touring. A 2023 Las Vegas residency was announced in November 2022.

The group evoked a "thrift shop aesthetic", in Bernard Gendron's words, by drawing from 1950s and 1960s pop sources, trash culture, and rock and roll. Schneider, Pierson, and Wilson sometimes use call-and-response-style vocals (Schneider's often humorous Sprechgesang contrasting with Wilson's and Pierson's melodic harmonies), and their guitar- and keyboard-driven instrumentation is their trademark sound, which was also set apart from their contemporaries by the unusual guitar tunings Ricky Wilson used on their earlier albums.